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TB-500 (Thymosin Beta-4) · 10mg

Total Price $506.65
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TB-500 (Thymosin Beta-4) 10mg – Licensed Peptides
TB-500 (Thymosin Beta-4) 10mg – lab report
TB-500 (Thymosin Beta-4) 10mg – lab report
TB-500 (Thymosin Beta-4) 10mg – Licensed Peptides
TB-500 (Thymosin Beta-4) 10mg – lab report
TB-500 (Thymosin Beta-4) 10mg – lab report
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TB-500 (Thymosin Beta-4) 10mg
Same as above
Included
  • 99%+ HPLC Purity — Independently verified by accredited US laboratory
  • Endotoxin-Screened — LAL tested, LPS-free, endotoxin report available
  • GMP-Certified Manufacturing — USA facility, ISO 9001:2015
  • Lyophilized for Stability — Shipped cold-packed, intact for reconstitution
Molecular Weight
Third Party Tested
APPLICATION
For Research Use only
Form
Lyophilized Powder
Storage
-20°C Long Term
Purity (HPLC)
99%+ Third Party Verified
Manufacture
USA / GMP

TB-500 (Thymosin Beta-4) · 10mg

Total Price $506.65
Discounted Price $354.65
Vials 5 vials
You Save
$152.00 30% OFF
Only $70.93 per vial Final price per vial after savings
⚠ Popular Peptides ⚠ Synthetic Peptides
Select Strength (mg)
99% HPLC Purity
Select Vials
Bulk pricing applied
📈 Upgrade to 10 vials and save an extra vs. buying 5 — nearly 3 vials included.
Your included vial Included · 2 for 1
TB-500 (Thymosin Beta-4) 10mg
Same as above
Included
  • 99%+ HPLC Purity — Independently verified by accredited US laboratory
  • Endotoxin-Screened — LAL tested, LPS-free, endotoxin report available
  • GMP-Certified Manufacturing — USA facility, ISO 9001:2015
  • Lyophilized for Stability — Shipped cold-packed, intact for reconstitution
Molecular Weight
Third Party Tested
APPLICATION
For Research Use only
Form
Lyophilized Powder
Storage
-20°C Long Term
Purity (HPLC)
99%+ Third Party Verified
Manufacture
USA / GMP
Reagent documentation

Scientific description

Structure, physicochemical data, analytical verification and safety documentation for TB-500. Supplied for in-vitro laboratory research only.

Reagent overview

Reagent
TB-500 (Thymosin Beta-4) 10mg
Composition
10 mg vial: TB-500
Form
Lyophilised powder, sealed vial
Chromatographic purity, current lot
>99.80%
CAS
77591-33-4
Lot on file
V260123-1Released 2/10/2026
Testing laboratory
Vanguard Laboratory, ISO/IEC 17025:2017, A2LA #6377.01.01
Download COA (PDF) Verify with Vanguard Laboratory Lot record in the Testing Library

Molecular structure

Two-dimensional structures generated with RDKit and drawn in the site palette. Tap a drawing to enlarge it. Below each drawing, the residue chain in one-letter code with the three-letter name and position; colours mark the side-chain class, a dashed outline marks a D-residue or a non-proteinogenic residue (lower-case letters are D-residues).

Acidic (Asp, Glu)Basic (Lys, Arg, His)Polar uncharged (Ser, Thr, Asn, Gln, Cys, Tyr)Hydrophobic (Ala, Val, Leu, Ile, Met, Phe, Trp)Gly / ProD- or non-proteinogenic residue

TB-500 (thymosin beta-4) N-acetyl thymosin beta-4, 43 residues

2D structure drawing of TB-500Tap to enlarge

2D depiction, C212H350N56O78S, generated from the PubChem connection table, CID 45382195.

AcSSer1DAsp2KLys3PPro4DAsp5MMet6AAla7EGlu8IIle9EGlu10KLys11FPhe12DAsp13KLys14SSer15KLys16LLeu17KLys18KLys19TThr20EGlu21TThr22QGln23EGlu24KLys25NAsn26PPro27LLeu28PPro29SSer30KLys31EGlu32TThr33IIle34EGlu35QGln36EGlu37KLys38QGln39AAla40GGly41EGlu42SSer43OH

Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH (terminal groups: N-terminal acetyl, C-terminal acid)

Physicochemical data

Formula, masses and identifiers from PubChem where a record exists, checked against an independent RDKit calculation and, for peptides, against the residue sequence. Theoretical pI, net charge at pH 7.4, GRAVY and the 280 nm extinction coefficient are calculated with Biopython ProtParam on the residue chain (Bjellqvist pK set; Kyte-Doolittle; Gill and von Hippel) and are marked "calculated"; they are not given where the chain contains non-proteinogenic residues.

TB-500 (thymosin beta-4)

Molecular formula
C212H350N56O78S
Average molecular weight
4963.5 g/mol
Monoisotopic mass
4960.486 Da
CAS number
77591-33-4
Sequence length
43 residues, N-terminal acetyl
Theoretical pI (calculated)
5.02 (free-terminus model)
Net charge at pH 7.4 (calculated)
-2.8
GRAVY hydropathy (calculated)
-1.702
Extinction coefficient, 280 nm (calculated)
0 M-1 cm-1 (no Trp, Tyr or Cys)
PubChem CID
45382195
InChIKey
UGPMCIBIHRSCBV-UHFFFAOYSA-N
Peptide class
Acidic, heat-stable beta-thymosin; G-actin sequestering peptide; sequence identical to UniProt P62328 residues 2 to 44
Appearance
White to off-white lyophilised powder
Solubility
Soluble in water (supplier specification); quantitative solubility not determined
Storage and handling
Store at -20 °C, desiccated and protected from light. The sealed powder tolerates short periods at ambient temperature during shipping.
Shelf life
Refer to the lot Certificate of Analysis; re-test date assigned per lot

Analytical verification, lot V260123-1

Tests reported for the current lot on file by Vanguard Laboratory, ISO/IEC 17025:2017, A2LA #6377.01.01 (released 2/10/2026): reversed-phase HPLC with UV detection (chromatographic purity by peak area, content against the label claim); LAL bacterial endotoxin; ICP-MS heavy metals. Only the tests listed below are part of this lot's report.

HPLC-UV chromatogram from the Certificate of Analysis, lot V260123-1Tap to enlarge

HPLC-UV chromatogram, full trace, from page 1 of the lot Certificate of Analysis (diode-array detector, 214 nm).

TestMethodResult
Chromatographic purityHPLC-UV/VIS>99.80%
Content (label claim 10 mg)HPLC-UV/VIS10.05 mg
Bacterial endotoxinLAL<5.00 EU/mg (LAL)
Heavy metalsICP-MSArsenic ND, Cadmium ND, Lead ND, Mercury ND
Purity reports Endotoxin reports Residual solvent reports Manufacturing process

Published research

Summaries of published papers, written for qualified researchers. They describe the published work, not this product.

In-vitro studiesThymosin beta-4 (TB-500) in endothelial cell migration assays: a published study summaryRead study →

Safety Data Sheet (SDS)

GHS-format safety data sheet, 16 sections. Revision 2026-11-04, version 1.0. "No data available" is stated wherever no measured data exist for the substance.

Download SDS (PDF)TB-500 (thymosin beta-4), CAS 77591-33-4
1.Identification
Product identifier
TB-500 (thymosin beta-4)
CAS number
77591-33-4
Product form
Lyophilised peptide, supplied by Licensed Peptides in sealed research packaging; the format of each product (vial, blend component, encapsulated research formulation or atomized solution) is stated on its product page.
Recommended use
Laboratory research reagent for in-vitro use by qualified researchers
Restrictions on use
Not for human or veterinary use. Not a drug, food, cosmetic or household product.
Supplier
Licensed Peptides, Inc., 1489 W Palmetto Park Rd, Boca Raton, FL 33486, USA
Supplier contact
service@licensedpeptides.com, +1 (855) 322-2214 (Mon to Fri, 8:30 AM to 6:30 PM ET)
Emergency telephone
+1 (855) 322-2214 (Mon to Fri, 8:30 AM to 6:30 PM ET). For a medical emergency contact local emergency services or a poison control centre.
2.Hazard identification
GHS classification
Not classified under GHS (Rev. 9) on the basis of the data available for this substance.
Signal word
None
Hazard statements
None assigned
Precautionary statements
None assigned. Handle as a laboratory chemical of unknown toxicity: avoid dust formation, avoid contact with eyes, skin and clothing, do not swallow.
Other hazards
Fine lyophilised powder may form dust. No data available on other hazards.
3.Composition / information on ingredients
Substance / mixture
Substance (synthetic peptide), may contain counter-ion and residual water from lyophilisation
Chemical name
Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH
Sequence (one-letter)
SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES
Sequence (three-letter)
Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH
CAS number
77591-33-4
Molecular formula
C212H350N56O78S
Concentration
Content as stated on the lot Certificate of Analysis (see /lab-reports/).
Impurities contributing to classification
None known
4.First-aid measures
General advice
Show this safety data sheet to the attending physician. Remove contaminated clothing.
If inhaled
Move the person to fresh air. If breathing is difficult, obtain medical attention.
In case of skin contact
Wash with plenty of soap and water. Obtain medical attention if irritation develops or persists.
In case of eye contact
Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. Obtain medical attention if irritation persists.
If swallowed
Rinse mouth with water. Do not induce vomiting. Obtain medical attention.
Most important effects, acute and delayed
No data available.
Indication of immediate medical attention
No data available. Care at the discretion of the attending physician.
5.Fire-fighting measures
Suitable extinguishing media
Water spray, dry chemical, carbon dioxide or alcohol-resistant foam, chosen for the surrounding fire.
Unsuitable extinguishing media
None known.
Specific hazards
Organic powder; combustion may release carbon oxides, nitrogen oxides and sulfur oxides.
Advice for fire-fighters
Wear self-contained breathing apparatus and full fire-fighting gear.
6.Accidental release measures
Personal precautions
Avoid dust formation. Wear gloves, eye protection and a laboratory coat. Ensure adequate ventilation.
Environmental precautions
Do not let the substance enter drains. Quantities supplied are milligram scale.
Containment and clean-up
Sweep up or wipe with a damp cloth without creating dust, place in a closed container for disposal, then clean the area with water.
7.Handling and storage
Precautions for safe handling
Handle in a laboratory setting by trained personnel. Avoid dust formation and contact with skin and eyes. Wash hands after handling. Keep the vial closed when not in use.
Conditions for safe storage
Store lyophilised at -20 °C in the original sealed vial, desiccated and protected from light. Keep away from strong oxidising agents. Short periods at ambient temperature during shipping are tolerated by the lyophilised powder.
Specific end use
Laboratory research reagent only.
8.Exposure controls / personal protection
Occupational exposure limits
None established for this substance.
Engineering controls
Handle the powder in a fume hood or ventilated enclosure. Eyewash station and safety shower should be available.
Eye / face protection
Safety glasses with side shields or chemical goggles (EN 166 or ANSI Z87.1).
Skin protection
Nitrile gloves inspected before use; laboratory coat.
Respiratory protection
Not normally required when handled in a fume hood. For dust-forming operations outside a hood use a particulate respirator (N95 or P2 type).
Hygiene measures
Do not eat, drink or smoke in the laboratory. Wash hands after handling.
9.Physical and chemical properties
Appearance
White to off-white lyophilised powder
Odour
Odourless
Molecular formula
C212H350N56O78S
Molecular weight (average)
4963.5 g/mol
Monoisotopic mass
4960.486 Da
Solubility
Soluble in water (supplier specification). Quantitative solubility: no data available.
pH, melting point, boiling point, flash point, vapour pressure, density, partition coefficient, auto-ignition temperature, decomposition temperature, viscosity
No data available
Flammability
No data available (organic powder, not expected to be readily flammable)
10.Stability and reactivity
Reactivity
No data available.
Chemical stability
Stable under the recommended storage conditions (lyophilised, -20 °C, desiccated, protected from light).
Possibility of hazardous reactions
None known.
Conditions to avoid
Moisture, prolonged exposure to light and elevated temperature; repeated freeze-thaw of solutions.
Incompatible materials
Strong oxidising agents, strong acids and bases.
Hazardous decomposition products
None known under normal storage. Combustion: carbon oxides and nitrogen oxides.
11.Toxicological information
Acute toxicity
No data available for this substance (all exposure routes).
Skin corrosion / irritation
No data available.
Serious eye damage / irritation
No data available.
Respiratory or skin sensitisation
No data available.
Germ cell mutagenicity
No data available.
Carcinogenicity
No data available. Not listed by IARC, NTP or OSHA.
Reproductive toxicity
No data available.
Specific target organ toxicity (single and repeated exposure)
No data available.
Aspiration hazard
No data available.
Additional information
This safety data sheet does not describe biological activity. The substance has not been evaluated for any use other than in-vitro laboratory research.
12.Ecological information
Ecotoxicity
No data available.
Persistence and degradability
No data available. As a peptide it is expected to be hydrolysed by environmental proteases.
Bioaccumulative potential
No data available.
Mobility in soil
No data available.
Other adverse effects
No data available.
13.Disposal considerations
Waste from residues
Dispose of as laboratory chemical waste through a licensed waste disposal contractor in accordance with local, state and federal regulations. Do not discharge to drains.
Contaminated packaging
Dispose of as unused product. Rinsed glass vials may be recycled where local rules allow.
14.Transport information
UN number
Not assigned
UN proper shipping name
Not regulated as a dangerous good
Transport hazard class
Not applicable (DOT, IATA, IMDG)
Packing group
Not applicable
Environmental hazards
Not classified as a marine pollutant
Special precautions
Ship cold-packed; the lyophilised powder tolerates short periods at ambient temperature.
15.Regulatory information
United States (FDA)
This substance is not approved by the US Food and Drug Administration as a drug, food, dietary supplement or cosmetic. It is supplied for in-vitro laboratory research only and is not for human or veterinary use.
OSHA Hazard Communication Standard (29 CFR 1910.1200)
Not classified as hazardous on the basis of available data.
TSCA (US)
Not evaluated. Supplied in research quantities only.
SARA 302 / 313, California Proposition 65
Not listed.
Other
Purchaser must be 21 years of age or older and a qualified researcher. The product may not be used in or on humans or animals.
16.Other information
Revision date
2026-11-04
Version
1.0
Prepared by
Licensed Peptides, Inc. (regulatory and quality documentation)
Data sources
PubChem CID 45382195 (formula, average and monoisotopic mass, InChIKey UGPMCIBIHRSCBV-UHFFFAOYSA-N); UniProt P62328 for the sequence; lot Certificate of Analysis for purity and content; GHS Revision 9 for section structure.
Disclaimer
The information in this safety data sheet is believed to be accurate as of the revision date and is provided for guidance on safe handling, storage and disposal in a laboratory setting. It is not a specification and does not constitute a warranty. The recipient is responsible for determining the suitability of the substance for the intended research application and for compliance with all applicable regulations.
Intended use. This product is not a drug, food, dietary supplement or cosmetic. It is supplied as a lyophilised laboratory reagent for in-vitro research by qualified researchers only and is not for human or veterinary use. The statements on this page have not been evaluated by the US Food and Drug Administration, and the product is not intended to diagnose, treat, cure or prevent any disease. Purchasers must be 21 years of age or older. Licensed Peptides is a chemical supplier, not a pharmacy.
99%+ Purity
99%+ Purity

Guaranteed per batch

HPLC + LAL
HPLC + LAL

Independent lab verified

Endotoxin-Free
Endotoxin-Free

Vanguard Laboratory · ISO/IEC 17025

GMP-Certified
GMP-Certified

USA-manufactured

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Same-Day Shipping

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Vendor Comparison

Why Researchers Choose Licensed Peptides

Not all peptide vendors hold themselves to the same verification standards.

Verification Standard Licensed Peptides Generic Vendors
HPLC Purity Analysis ✓ 99%+ Every Batch ✗ Often Not Disclosed
Endotoxin Screening (LAL) ✓ Every Product ✗ Industry Exception
GMP-Certified USA Manufacture ✓ ISO 9001:2015 ✗ Often Overseas
COA Published & Downloadable ✓ Every Lot ✗ Inconsistent
Same-Day USA Fulfillment ✓ Before 4PM PST ✗ 3-10 Day Lead Time
Research Questions

Frequently Asked Questions

It is a laboratory research peptide modeled after Thymosin Beta-4 and used to study actinrelated signaling and cellular behavior

Researchers examine TB-500 for its role in actin regulation, cellular migration, angiogenic signaling, and tissue-structure studies.

No. TB-500 represents a peptide fragment modeled after the active region of Thymosin Beta-4 and is used for research purposes only.

It is studied for its interaction with actin-related pathways and cellular movement in experimental models.

Because it is studied across multiple tissue systems in experimental models rather than a single localized pathway.

Common research areas include actin regulation, cellular migration, tissue-structure analysis, vascular studies, connective-tissue research, and inflammation-related experiments.

Yes. Researchers may explore combinations in controlled experimental designs to study pathway interactions.

Published studies are used to inform laboratory research context only and do not indicate approval for human or animal use.

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